Development of Freeze-Drying Cycles for Pharmaceutical Products Using a Micro Freeze-Dryer
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چکیده
منابع مشابه
In-line and Off-line Optimization of Freeze-drying Cycles for Pharmaceutical Products
Model based tools allow optimizing the freeze-drying of a pharmaceutical formulation in a specific freeze-dryer, thus minimizing the duration of the process, beside maintaining product temperature below a limit value to preserve product quality. This paper is focused on the comparison of the results that can be obtained optimizing the process either off-line, using the design space of the formu...
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Lyophilization, the removal of water by freezing and then volatilization at low pressure and temperature, has been employed as a standard long-term preservation method for many filamentous fungi. The method outlined involves the use of standard shelf freeze-drying and skimmed milk as a suspending solution/lyoprotectant. This approach has been employed to freeze-dry the majority of the 50,000 fu...
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WAGMAN, JACK (U.S. Army Biological Laboratories, Frederick, Md.) AND EDWARD J. WENECK. Preservation of bacteria by circulating-gas freeze drying. Appl. Microbiol. 11:244-248. 1963.-Water-washed Serratia marcescens and Escherichia coli were freeze dried in a circulating-gas system at atmospheric pressure. This convective procedure resulted in a substantially higher survival of organisms than cou...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2019.10.053